LMP1503H Course Schedule - January 2011
NOTE: Please contact Shirley Thompson at 416-813-5998 (Thompson@sickkids.ca) if you require additional information
Location: FitzGerald Building, Room #77 with the exception of student presentations on March 23rd 2011
Time: 10:00-12:00 (Wednesdays)
Signal transduction mechanisms will be described and illustrated by defects in specific human disease states.
|
Lectures |
Date |
| 1. |
Role of Glycolipids in Signal Transduction Pathways
Dr. C. Lingwood (Tel: 813 5998/fax: 813-5993)
Email: cling@sickkids.on.ca
- Overview of glycolipid structure and the signal transduction pathways in
which glycolipids play a role including the mechanism of action of cholera
toxin and verotoxin (Shiga toxin)
- the role of glycolipids in tyrosine phosphorylation and receptor kinase
signal transduction,
- Glycolipids in lipid rafts –role in T cell signaling, HIV infection and
intracellular traffic. |
Jan 12 |
| 2. |
Signalling Pathways in Cancer
Sima Salashor
Email: salahshor@scienceha.com
Three decades after discovery of the first oncogene and tumor suppressor
gene, many hurdles still remain in the race against cancer. In this lecture, we
explore the role of different signaling pathways in cancer initiation and
progression. Understanding the complex role of each pathway in different
stages of tumorigenesis is the key in development of new generation of
diagnostic tests and anti-cancer drugs.
Lecture Outline
- Different signaling pathways involved in hereditary and sporadic colorectal
cancer
- The possible role of environment in deregulation of signaling pathways in
cancer cells |
Jan 19 |
| 3. |
Epidermal Growth Factor Receptor Signaling in Cancer
Michael Moran
Email: m.moran@utoronto.ca
|
Jan 26 |
| 4. |
Lipid Signaling via Nuclear Orphan Receptors
Dr. Khosrow Adeli
Email: Khosrow.adeli@sickkids.ca
-
The lecture will focus on cholesterol and fatty acid signalling and
metabolism, and the role of key receptors including SREBP and LXR.
-
Dysregulation of these signaling pathways will also be discussed in insulin
resistance, dyslipidemia, and type 2 diabetes. |
Feb 2 |
| 5. |
ER-stress pathways and lysosomal storage disease
Dr. D. Mahuran (Tel: 813-6161/fax: 813-8700)
Email: hex@sickkids.on.caTitle:
Title: Manipulating the Endoplasmic Reticulum Quality Control (ERQC) System as a Therapeutic Approach for Lysosomal Storage diseases
-Two Model Lysosomal Storage Diseases: Tay-Sachs and Gaucher
* Normal synthesis and intracellular transport pathways
* Common mutations and genotype/ phenotype correlations
* Approaches to treatment
-The Endoplasmic Reticulum (ER) is a Microenvironment that Promotes Protein Folding and Protects the Cell from Misfolded Proteins though its ERQC System
* ER-stress Pathways
-The Unfolded Protein Response (UPR): The Ubiquitin Proteasome System(UPS)
-ER Activated Autophagy (ERAA): The Macroautophagy Lysosome System (MALS)
* The FoldEx Model of the ERQC
-Getting in and out from Calnexin/Calreticulin cycles
-Pharmacological Chaperones (PC)
-Partial restoration of mutant enzyme homeostasis by altering calcium homeostasis.
-Manipulating cellular proteostasis to enhance protein folding
|
Feb 9 |
| 6. |
Developmental Signaling and Transcription
Dr. H. Elsholtz (Tel: 978 8782/fax: 978-4108)
Email: h.elsholtz@utoronto.ca
The coordinated regulation of gene expression is critical for normal embryonic development, and enables organisms to respond to a host of extracellular signals (eg. endocrine, neural, immunological). Gene expression can be regulated at numerous levels, frequently at the initiation of transcription. This lecture gives a brief introduction to transcriptional control mechanisms, then focuses on the role of specific transcription factors, including members of the 'homeodomain-containing' family of factors in developmental signaling. The consequences of mutations or aberrant regulation of these factors is discussed in experimental and clinical contexts.
|
Feb 16 |
| 7. |
Role of Nod-like receptors in bacterial infection and inflammation
Stephen Girardin
Email: stephen.girardin@utoronto.ca
The key role played by Nod1 and Nod2, in the detection of bacterial
peptidoglycan and the resulting induction of signalling cascades and
inflammation, will be defined. The link between mutations in Nod2 gene and
the susceptibility to Crohn's disease will be discussed.
|
Feb 23 |
| 8. |
Wnt signalling in development and disease
Benjamin Alman
email: Benjamin.Alman@SickKids.ca
Outline to be announced.
|
Mar 2 |
| 9. |
HIV-mediated signal transduction
Donald Branch (Tel: 416-313-4458)
Email: Don.Branch@utoronto.ca
When human immunodeficiency virus (HIV) infects cells, it initiates
signaling pathways that are necessary for the virus to complete its life cycle,
to eventually produce progeny virions. The various reported signaling
pathways induced by HIV infection will be discussed and a model proposed
of signal transduction necessary for successful infection with this virus.
|
Mar 9 |
| 10. |
Student presentations 9am-5:00pm Room 1527 Hill Wing |
Mar 23 |
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